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desvenlafaxine will raise the level or impact of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Warning/Check. Desvenlafaxine inhibits CYP2D6; with larger desvenlafaxine doses (ie, 400 mg) minimize the CYP2D6 substrate dose by around fifty%; no dosage adjustment needed with desvenlafaxine doses 7 consecutive days straight away previous